HYPERTEXT MANUAL OF CLINICAL PHARMACOLOGY
DEMONSTRATION


"Hypertext" has become a fashionable word in the computer
world. The word refers to a technique for accessing information
in a nonlinear and highly efficient fashion. This is ac-
complished by placing "hyperlink" keywords in the text and using
the computer to jump, on command, to the information file de-
scribed by the keyword. The files in this archive constitute a
draft of the first 6 chapters from a proposed full
hypertext manual (which will be produced if there is enough
interest in it). Features included in this draft
include: data useful for the selection and prescribing
of drugs used in major cardiovascular diseases
(angina, congestive heart failure, arrhythmias, hyperten-
sion, edema), and a calculator suitable for performing dose con-
versions, surface area calculations, and creatinine clearance
estimates.

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NOTE: The purpose of this draft version is to test
its functionality, not to provide clinical information.
The pharmacologic accuracy of the data is NOT GUARANTEED
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Hardware and software requirements:
1. Either: a hard disk (drive C) with at least 510 KB (half a
megabyte) of space available,
OR: a high-density floppy drive (720 KB, 1.2 MB, or 1.44 MB)
as drive B.
2. MS-DOS or PC-DOS, version 2.1 or higher.

Using the Hypertext Manual:
Starting the program: Once the Manual has been un-arc'ed on
your working disk, start it by typing "hy-
per".
Using the Help (F1) screen: To review the commands avail-
able, press the F1 function key. When the help screen is dis-
played, pressing any key will return to the file pre-
viously displayed.
Moving within a file: The files in the Manual vary from 20
lines (1 screen) to several hundred lines (many
screens). Move around within a file by using the
PgUp/PgDn keys. Make sure "Numlock" is off. If Numlock is
on, "NUM" will be displayed near the left end of the
status line at the bottom of the screen, and the ma-
chine will beep (see errors, below) when you press the
Enter key.
Moving between hypertext links:
1.Use the up and down arrow keys. Make sure that "Num-
lock" is off. The up/down arrows move the
highlight area to previous/next link (angle bracket)
words. When you first load a file, no angle bracket
link will be highlighted. Pressing either the up or
the down arrow key will highlight the first keyword.
When a link is highlighted, pressing the Enter key
will cause the program to load (jump to) the topic
highlighted.
2. Use the Esc, left arrow, and right arrow keys (the
arrow keys are part of the number pad at the right
side of the keyboard). These moves do not depend on
having an angle bracket word highlighted. Pressing Esc returns you to the main menu screen. Pressing
the left arrow returns you to the preceding file.

Errors: When the program cannot execute a requested move,
an error is indicated by an audible "beep" from the ma-
chine. The most common cause of a beep is a request to
page down (PgDn key) when the last screen of a file is
displayed, ie, it is not possible to scroll down fur-
ther. The beep in this case reflects only a warning
that the computer cannot proceed further in the file.
A true error that may occur is a request to jump to a
nonexistent file (there may be a file names in angle
brackets in the text that I have not yet implemented).
This type of error results in a beep and a message on
the "status line" at the bottom of the screen.

Exiting the program: Return to the main screen if you are
not there already by pressing Esc. More than one press
may be required. Then press "q" for quit (see menu at
bottom of screen). The program will ask for confirma-
tion of your intention to quit. Type "y" for yes if you
wish to exit.

NOTE: The hypertext utility that provides the "engine" for the
Hypertext Manual is PC-Hypertext, a program written by MaxThink,
Inc, Kensington, CA, (415) 428-0104. The Hypertext Manual of
Clinical Pharmacology was written by B.G. Katzung, Department of
Pharmacology, Box 0450, University of California, San Francisco,
CA 94143. It is based on a hardcopy printed version called
"Clinical Pharmacology '88/'89, ((c) Appleton & Lange, 1988).
I would appreciate your comments and criticisms of
this Manual.

B.G. Katzung, 6 February 1989